Recent Projects

Download Shareware

Contact NeoDym

Links to Other Sites


Computer Modeling of Near Infra-Red Spectroscopy

NeoDym has studied the complete end-to-end modeling of an instrument which will determine the level of glucose in blood by measuring the infra-red absorption spectrum.

Infra-red molecular absorption spectra do not have sharp spectral lines like the spectra from many atoms. They are very broad and the peaks all run into each other. Water is also very absorptive in the near infra-red and in the region where glucose is active. This is at a wavelength of just under 1000 nanometers wavelength.

The simulation started by modeling the spectral output of the quartz halogen lamp, modeling the absorption of the blood with 10 main analytes present and then modeling the detector/electronics and the data reduction process. From the simulation we were able to determine the major contributors to error in the glucose estimate and how they interacted.

Two types of data reduction were modelled - i.e. Partial Least Squares (PLS) and Classical Least Squares. PLS requires no assumptions about the spectra of the various analytes, but does require extensive calibration and 'training' of the PLS algorithm. CLS, on the other hand, utilises the known spectra of the blood analytes, but does not require a calibration or training process.

Copyright (c) NeoDym, 1997-2003

Site created & maintained by: